After all in-vitro tests the remaining drugs candidates could be screened in-vivo on Hamsters` model. Moreover, we provide services for pharmacokinetic measure, medical chemistry optimisation and further scaffold validation.
Treatment initiate 1 hour before infection and continue twice/day.
SARS-CoV-2 RNA is measure in nasal washes and lungs of animals 3 days p.i.
Tested drug – proposed inhibitor
Format: single compound test
Leads molecules chemistry optimisation for improving their physico-chemicals properties.
The final validation of lead series. At the very end you obtain a full pre-clinical candidate.