Hit-to-Lead Optimisation

After all in-vitro tests the remaining drugs candidates could be screened in-vivo on Hamsters` model. Moreover, we provide services for pharmacokinetic measure, medical chemistry optimisation and further scaffold validation.

Hamsters` model

Treatment initiate 1 hour before infection and continue twice/day.

SARS-CoV-2 RNA is measure in nasal washes and lungs of animals 3 days p.i.

Tested drug – proposed inhibitor

Format: single compound test

MedChem

Leads molecules chemistry optimisation for improving their physico-chemicals properties.

ADME

The main pharmacokinetics tests:

- Cythocrome P450

- Microsomal Stability

- Caco-2 Permeability

- Protein Binding

- etc

Scaffold Validation

The final validation of lead series. At the very end you obtain a full pre-clinical candidate.